BIOTECH MEM

Question Answer
anibi angiogenesis inhibitor
bac-ba- bacterium
cir-ci- circulatory
fung-fu- fungus
ki(n)-ki- interleukin
les inflammatory lesions
lim-li- immune system
mul muscoskeletal system
neur-ne- nervous system
os-so bone
toxa-tox toxin
vir-vi virus
o/omab mouse
xi/ximab chimeric
zu/zumab humanized
u/umab human
a rat
e hamster
i primate
axo rat/mouse
I Tositumomab, Y Ibritumomab CD-20 (radioactive link cytotoxic delivery) Non hodgkin's lymphoma
Rituximab CD-20 (ADCC, CDCC) non hodgkin's lymphoma
Brentuximab Vedotin CD30 (antimitotic link cytotoxic delivery) hodgkin's lymphoma
Gemtuxumab Calicheamicin CD33 (antibiotic link cytotoxic delivery) acute myeloid leukemia
Alemtuzumab CD52 (ADCC, CDCC) B cell chronic lymphocytic leukemia (CLL)
Cetuximab EGFR1 (Block EGFR; epidermal growth factor) colorectal cancer
Traztuzmab HER2 (ADCC) breast cancer
Bevacizumab VEGF (VEGF receptor block) non-small cell lung cancer (NSCLS) colorectal cancer
Nivolumab PD1 (PD1 receptor block) metastatic melanoma, NSCLS
Muromonab CD3 (CD3 blocker) kidney allograft rejection. Steroid resistant heart transplant Tcell
Daclizumab CD25 (IL-2 receptor (CD25) blocker) acute rejection of kidney transplants T cell
Infliximab, (TNF alpha blocker) T cell inflammatory
Adalimumab, (TNF alpha blocker) T cell inflammatory
Colimumab (TNF alpha blocker) T cell inflammatory
Basiliximab CD25 (IL-2 receptor (CD25) blocker) acute rejection of kidney transplants T cell
Panitumumab EGFR1 (Block EGFR; epidermal growth factor) colorectal cancer
Native Immunity components 1rst line Physical barriers: skin, mucous, PH (stomach acid), sweat, perspiration (3-4 PH b/c lactic acid)
Native Immunity components 2nd line Compliment/Immune cells: Neutrophils, monocyte, macrophages, myeloid cells/path. Can also produce cytokines and chemokines=> activate other 2nd line defense Other 2nd line defense=> INFLAMMATION*
Humoral Response (antibody response) professional cells of the immune system used T cellB cell Dendritic cells [best antigen presenter; close to mucus membrane]Macrophage [present antigen to antigen presenting cells]Adaptive immunity.
T Cell: receptor for CD 4 receptor “Cluster differentiation” will recognized ACP, Recognize MHC 2. T cell can bind to B cell receptor and stimulate B cell. B cells produces antibody for specific antigen./ or opsinization (memory cells produced)Humoral immunity
Cell Mediated Response all nucleated cells have the ability to present MHC1 molecule. All proteins in cell are degraded in the proteasome.Broken protein fragments after proteasomal degradation are presented on cell surface
T Cell CD8 cytotoxic T cell: recognizes MHC1 as self or non self because it was exposed to itself in development. Kills cells. cell mediated immunity
Simple vaccine 1 antigen for 1 disease
Multivalent vaccine 2 or more antigens for 1 disease
Polyvalent vaccine 2 or more antigens for 2 or more diseases
Inactivated: Flu Vaccine INACTIVATED/ whole?Trivalent vaccine: H1N1, H3N2 (type A) + Brisbane strain (B type) Quadravalent vaccine: H1N1, H3N2 (type A) + Brisbane strain, Thailand strain (B type)
Hemagglutinin H which allows for the attachment of the virus to attach to a tropic (Antigen presenting cell)
Neuraminidase (sailidase) N which allows for the entry and exit of epithelial/antigen presenting/tropic cells.
Gardasil against HPV. strain 16, 18 cause 70% cervical cancer; strain 6,11 cause 90% STDs. (L1 protein for 6, 11, 16,18) all brought together=virus-like particles (VLP). : (6, 11, 16,18) and another 5 for cancers (31, 33, 45, 52, 58)
Aluminum salts Adjuvant, act as depot for antigen (trigger humoral response) MCH2. aluminumphosphate/hydroxyphosphate/sulfate -insoluble: provides an adsorbent surface for vaccine because vaccine is a “suspension”
Immuno modulatory adjuvants: MF59AS3ISCOMS
MF 59 oil in water emulsion 3 components 1. Span 85 => sorbitol trioleate 2. Squalene => lipid 3. Polysorbate 80 => detergent Antigen + MF59=> vaccine => TH1 response (no depot); cell mediated IgG
AS3: Components 1. Squalene = High TH1 response 2. Alpha- Tocopherol (vitamin E) = down regulate TH2 response 3. Polysorbate= Up regulate TH1 response
ISCOMS: immune stimulatory complexes: components: 1. cholesterol => form a cage 2. phospholipids => form a cage (30-40 nm=optimum size for phagocytosis) 3. Quil A (saponin)= Isolated from tree bark= gives cage shape. Antigen+ISCOMS=>cage like structure formed around vaccine MHC2 and MHC1 response
certolizumab pegol TNF alpha anti inflam. binds with longer half life to TNF alpha
Etanercept TNF alpha decoy receptor. Fc portion of human antibody dimer of TNFR2 (p75)
Alirocumab PCSK0 hypercholestroloma decgrades the pcsk9 enzyme that degrades LDL receptors
Evolovumab PCSK0 hypercholestroloma decgrades the pcsk9 enzyme that degrades LDL receptors

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